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Age-related macular degeneration has become the most common cause of blindness. With population ageing AMD will become an ever more prevalent cause of visual loss unless more effective modes of treatment will be found. Here, an expert panel of experienced clinicians and eminent basic scientists provide for an authoritative review on the pathogenesis, epidemiology and risk factors, diagnostic methods and imaging modalities for age-related macular degeneration. Many photographs and diagrams add to a clear understanding.