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This book describes the history, origin and basic insights of bioactive materials. It presents a chapter dedicated to hydroxyapatite mineral, its formation and its bioactive properties. The authors address how the cytotoxicity is a determining step for the bioactivity. Applications of bioactive materials in tissue regeneration, bone regeneration and cancer therapy are also covered. Silicate, metallic and mesoporous glasses are described, as well as the challenges and future perspectives on research in this field.