Biosensors for Single-Cell Analysis

Biosensors for Single-Cell Analysis explores a wide range of biosensor technologies and the application of these to single-cell characterization and analysis. The book is divided in terms of five key biophysical and chemical single-cell properties, considering proteomic, metabolic, electrical, mechanical and optical properties. Each chapter features key definitions, case studies providing detailed guidance for researches to replicate their own work, tutorial sections, evaluations of the current state of the field and future developments. Microfluidic approaches to characterization, such as microfluidic impedance flow cytometry and microfluidic flow cytometry, are considered alongside more conventional approaches, such as mass spectroscopy, fluorescent and mass flow cytometry. Additionally, key types of biosensors are covered, including atomic force microscopy, micropipette aspiration, optical tweezers, microfluidic hydrodynamic stretchers, microfluidic constriction channel and microfluidic optical stretchers. Biosensors for Single-Cell Analysis is a useful reference on the application of biosensor technology as an analytical tool for single-cell investigation, providing an overview from fundamental knowledge to practice. Includes chapters focused on key single-cell properties, such as proteomic, metabolic and mechanical characterizationFeatures case studies illustrating application of biosensors for single-cell analysisConsiders microfluidic approaches for each single-cell property discussedExplores future directions for single-cell analysis and biosensor technology in this field