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This book focuses primarily on the development of effective gene therapy approaches for HIV infection, including the improvement of gene transfer vectors, procedures for the ex-vivo manipulation and transduction of T-lymphocytes and hematopoietic stem cells, and preclinical testing of HIV inhibition strategies. It provides a balanced perspective of the many accomplishments in this field as well as the problems which need to be solved in order to develop safe and effective therapies which benefit persons with HIV infection.