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This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to discuss the effects of mitochondria in disease; the role of mitochondria as a drug target in kidney, neurodegenerative, and cardiovascular disease; and mitochondrial remodeling and targeting in cancer. Thus, the chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
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