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This book constitutes the referred§proceedings of the First International Workshop on Patch-based Techniques in§Medical Images, Patch-MI 2015, which was held in conjunction with MICCAI 2015,§in Munich, Germany, in October 2015.§§The 25 full papers presented§in this volume were carefully reviewed and selected from 35 submissions. The§topics covered are such as image segmentation of anatomical structures or lesions;§image enhancement; computer-aided prognostic and diagnostic; multi-modality§fusion; mono and multi modal image synthesis; image retrieval; dynamic,§functional physiologic and anatomic imaging; super-pixel/voxel in medical image§analysis; sparse dictionary learning and sparse coding; analysis of 2D, 2D+t,§3D, 3D+t, 4D, and 4D+t data.