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Sample Size Determination in Clinical Trials with Multiple Endpoints

Name: Sample Size Determination in Clinical Trials with Multiple Endpoints
Brand: Springer International Publishing AG
SKU: 09378378
Price: 75.9 EUR
Availability: InStock
Author: Takashi Sozu
ISBN: 9783319220048

Език

Английски език

Книга С меки корици

Код Либристо: 09378378

Издателство Springer International Publishing AG, август 2015

This book integrates recent methodological developments for calculating the sample size and power in... Цялото описание

Код Либристо: 09378378

184 b

75.90 €

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This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area.§§The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also brie y examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespeci ed non-ordering of endpoints.§§