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Effects of dexamethasone on glucocorticoid receptors in ovine placenta

Name: Effects of dexamethasone on glucocorticoid receptors in ovine placenta
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 10944115
Price: 52.93 EUR
Availability: InStock
Author: Hongkai Shang
ISBN: 9783838152295

Hongkai Shang

Language

English

Book Paperback

Libristo code: 10944115

Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG, April 2016

this study for the first time demonstrated the presence of three different GR_-BNC-subtypes in sheep... Full description

Libristo code: 10944115

129 b

52.93 €

103.53 лв

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this study for the first time demonstrated the presence of three different GR_-BNC-subtypes in sheep placenta. The number of GR_ BNCs was regulated by early DEX treatment and this effect was long lasting and sex-, subtype-, placentome-subtype- and level-dependent. Early in pregnancy, DEX may reduce the function of BNCs via increased proportion of "inactive" BNC compared to controls. Apoptosis may play an important role in the conversion among the three BNC-subtypes. This is supported by co-localisation studies with caspase-3, oPL and GR_. Late in pregnancy, early DEX treatment resulted in an increased mean percentage of "active" BNC and decreased the mean percentage of "inactive/intermediate" BNC compared to controls, suggesting that early DEX treatment possibly reduces the sensitivity of GR_ in BNCs to the natural rise of fetal cortisol levels near term. While in female fetuses a constant placental GC sensitivity is maintained, possibly in terms of a preferential survival strategy for ensuring reproductive capacity and species conservation, it seems that in male fetuses, due to increased GC exposure, the placenta becomes at least temporarily GC-resistant.