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Evolving Methods for Macromolecular Crystallography

Name: Evolving Methods for Macromolecular Crystallography
Brand: Springer-Verlag New York Inc.
SKU: 01417379
Price: 161.78 EUR
Availability: InStock
Author: Randy J. Read
ISBN: 9781402063152

The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents

Randy J. Read

Joel L. Sussman

Language

English

Book Paperback

Libristo code: 01417379

Publishers Springer-Verlag New York Inc., June 2007

X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules... Full description

Libristo code: 01417379

394 b

161.78 €

316.41 лв

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X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules at atomic resolution. These structures are central to understanding the detailed mechanisms of biological processes, and to discovering novel therapeutics using a structure-based approach. As yet, structures are known for only a small fraction of the proteins encoded by human and pathogenic genomes. To counter the myriad modern threats of disease, there is an urgent need to determine the structures of the thousands of proteins whose structure and function remain unknown. This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis, and show how modern high-throughput methods are contributing to a deeper understanding of medical problems.