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Formulation and Characterization of Diclofenac Sodium Gel

Name: Formulation and Characterization of Diclofenac Sodium Gel
Brand: LAP LAMBERT Academic Publishing
SKU: 43679268
Price: 41.21 EUR
Availability: InStock
Author: Ritesh Limjhe
ISBN: 9786206167075

Ritesh Limjhe

Language

English

Book Paperback

Libristo code: 43679268

Publishers LAP LAMBERT Academic Publishing, May 2023

In this present study it can be concluded that topical gel formulations containing drug Diclofenac s... Full description

Libristo code: 43679268

100 b

41.21 €

80.60 лв

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In this present study it can be concluded that topical gel formulations containing drug Diclofenac sodium were prepared with different concentration of gelling agents (carbopol-940/934/ HPMC 3K), which have shown an acceptable results in various evaluation studies. Gel was characterized on basis of various evaluation paeameters, All prepared gel showed acceptable physical properties concerning color, odour, consistency, uniformity, homogeneity, pH value, viscosity and spreadability. An in vitro drug release study was carried out using an egg membrane by using instrument franz's diffusion cell (dolphin).The results indicates that in over 24 hours of total study up to 90.12 % of diclofenac sodium drug is release through the membrane. According to the results obtained from this study, it was concluded that Diclofenac Sodium was successfully incorporated into the carbopol formulation to obtain a gel. F5 gel formulation showed good pH value, conductivity, viscosity, spreadability, and stability before and after the 12 days in the freeze-thaw cycle. Therefore, it was concluded that the formulation F5, could be very promising alternative for the topical or transdermal treatment.