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Microparticle Formation by Spray-Freeze-Drying

Name: Microparticle Formation by Spray-Freeze-Drying
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 07139440
Price: 74.87 EUR
Availability: InStock
Author: Sebastian Vonhoff
ISBN: 9783838117713

The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

Sebastian Vonhoff

Language

English

Book Paperback

Libristo code: 07139440

Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG, June 2010

This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process c... Full description

Libristo code: 07139440

182 b

74.87 €

146.43 лв

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This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the third part of this thesis. In the fourth and last part, different formulations containing a mixture of alpha-chymotrypsin and various excipients are evaluated for their stability.