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Pharmacology of Neurotransmitter Release

Name: Pharmacology of Neurotransmitter Release
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01569199
Price: 204.22 EUR
Availability: InStock
Author: Thomas C. Südhof
ISBN: 9783540748045

Thomas C. Südhof

Klaus Starke

Language

English

Book Hardback

Libristo code: 01569199

Publishers Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, December 2007

It has been known for half a century that neurotransmitters are released in preformed quanta, that t... Full description

Libristo code: 01569199

497 b

204.22 €

399.41 лв

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It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.